What Is The Difference Between Mesotherapy and Kybella?

Mesotherapy by Apres Beauty and Wellness in Sparta NJ

Various treatments are available today to address stubborn fat and achieve a more sculpted appearance. Two popular options are Mesotherapy and Kybella. 

These treatments offer practical solutions for reducing unwanted fat but differ in their approaches and outcomes. 

In this article, we’ll explore the differences between Mesotherapy and Kybella to help you decide which one may be right for you.

Let’s first start with Mesotherapy…


Mesotherapy is a minimally invasive cosmetic procedure that aims to reduce localized fat deposits and improve the appearance of cellulite. It was developed in France in the 1950s and has gained popularity worldwide for its non-surgical approach to fat reduction. 

The procedure involves injecting a mixture of pharmaceuticals, vitamins, minerals, and other active ingredients directly into the subcutaneous fat layer beneath the skin.

How Mesotherapy Works

The injected cocktail of ingredients in Mesotherapy serves multiple purposes. Firstly, it helps to break down and emulsify the fat cells, making it easier for the body to eliminate them through natural processes. 

Second, the active substances might promote the synthesis of elastin and collagen, tightening the skin and improving its texture in the treated area. Mesotherapy can be applied to the face, neck, arms, thighs, belly, and other body areas.

Benefits of Mesotherapy

Mesotherapy offers several advantages:

  • Non-Surgical: Unlike surgical procedures such as liposuction, Mesotherapy is minimally invasive, requiring only injections and no incisions or anesthesia.
  • Minimal Downtime: Following the operation, patients can usually return to their regular routines with little discomfort or bruises.
  • Versatility: Mesotherapy is a customizable choice for patients, as it may be adapted to target specific regions of concern.

Each person may respond differently to Mesotherapy, and more sessions may produce the desired effects.


An FDA-approved injectable medication called Kybella is intended to remove submental fat. Again, most people referred to it as a double chin. Kybella is a synthetic version of deoxycholic acid. 

For those who don’t know, it’s a naturally occurring element that aids in the body’s absorption and breakdown of dietary fat. Allergan is the company that created Botox.

How Kybella Works

The active ingredient in Kybella, deoxycholic acid, is injected directly into the submental fat tissue beneath the chin. Once injected, it disrupts the fat cell membranes, causing them to break down. 

Over time, the body’s lymphatic system clears the damaged fat cells. This leads to a gradual reduction in the appearance of a double chin.

Benefits of Kybella

Kybella offers some distinct advantages:

  • Targeted Fat Reduction: Kybella is specifically designed to reduce fat under the chin, making it an ideal treatment for individuals concerned about their profile.
  • Minimal Discomfort: The procedure involves a series of injections that are generally well-tolerated by patients. Local anesthesia can be applied to minimize discomfort.
  • No Surgery or Downtime: Kybella is a non-surgical approach. We know that, but the best thing about it is that it allows you to return to your daily activities afterward. 

It’s important to understand that Kybella is primarily used for submental fat reduction and may not be suitable for addressing fat in other body areas.

Mesotherapy vs. Kybella: Key Differences

Now that we have a clear understanding of both Mesotherapy and Kybella let’s compare the two treatments in critical areas:

Targeted Areas:

  • Mesotherapy: Can be used on various body parts, including the face, neck, arms, abdomen, and thighs.
  • Kybella: Specifically designed for reducing submental fat under the chin.

Treatment Approach:

  • Mesotherapy: Involves injecting a mixture of pharmaceuticals, vitamins, minerals, and other active ingredients.
  • Kybella: Uses a synthetic form of deoxycholic acid to break down fat cells.


  • Mesotherapy: Offers flexibility in targeting different areas of concern.
  • Kybella: Primarily targets submental fat and is unsuitable for other body areas.

Number of Sessions:

  • Mesotherapy: This may require multiple sessions to achieve the desired results.
  • Kybella: Typically involves a series of treatments spaced several weeks apart.

Recovery Time:

  • Mesotherapy: Minimal downtime, with patients often resuming normal activities shortly after the procedure.
  • Kybella: Minimal to no downtime, with most patients returning to their routines after each session.


  • Mesotherapy: Results can vary and may take some time to become apparent.
  • Kybella: Gradual reduction in submental fat over several sessions, with visible results in a few weeks to a few months.

Choosing The Right Treatment For You

The choice between Mesotherapy and Kybella depends on your specific concerns and goals. If you’re looking to address submental fat and achieve jawline, Kybella may be the ideal choice. 

However, Mesotherapy offers greater versatility if you have localized fat deposits in areas other than chemotherapy, which is a non-surgical approach.

Who Is an Ideal Candidate For Mesotherapy and Kybella?

The ideal candidates for Mesotherapy and Kybella are individuals dealing with localized fat deposits or those seeking to reduce a double chin, specifically in the case of Kybella. 

To determine which treatment best suits your unique needs, we strongly recommend consulting with our specialists, who can provide personalized guidance.

When Can I Expect to See Results with Mesotherapy and Kybella?

The timeline for visible results varies between Mesotherapy and Kybella:

  • Mesotherapy: Results typically become noticeable after undergoing several treatment sessions. The exact number of sessions required may vary depending on individual factors.
  • Kybella: Visible results are often achieved within 2 to 4 treatment sessions. Kybella’s effectiveness in limiting fat can improve a frame span. 

How Long Do The Results of Mesotherapy and Kybella Last?

The duration of results differs for Mesotherapy and Kybella:

  • Mesotherapy: Results can endure significantly with proper maintenance and a healthy lifestyle. Consistency in follow-up treatments and lifestyle choices can help maintain the desired outcome.
  • Kybella: Kybella provides a permanent reduction in fat once the desired results are achieved. This means that the fat cells targeted by Kybella will not return, offering a long-lasting solution for submental fat reduction.

Our Takeaway

Mesotherapy and Kybella offer effective options for individuals seeking to enhance their appearance. While Mesotherapy is versatile and can target various body areas, Kybella reduces submental fat and improves the profile.

Your specific concerns and goals should guide the choice between these treatments. To explore your options further and determine which treatment is right for you, consult a trusted practitioner who can provide expert guidance. 

So, whether you’re interested in Mesotherapy or Kybella, take the first step towards a more sculpted you by seeking professional advice.

Book an appointment here at Apres Beauty and Wellness to discover the best non-surgical fat reduction solution for your unique needs.


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